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Once in the host gut, Necator tends to cause a prolonged infection, generally 1–5 years (many worms die within a year or two of infecting), though some adult worms have been recorded to live for 15 years or more.

On the other hand, Ancylostoma adults are short-lived, surviving on average for only about 6 months.

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Additionally, males can be distinguished from females based on the presence of a prominent posterior copulatory bursa. Generally, they live for only a few weeks at most under natural conditions, and die almost immediately on exposure to direct sunlight or desiccation.

Other animals such as birds, dogs, and cats may also be affected. This bend forms a definitive hook shape at the anterior end for which hookworms are named. See the image for the biological life cycle of the hookworm where it thrives in warm earth where temperatures are over 18 °C.

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